CLASP2 antibody (C-Term)

Catalog No. ABIN391268

Product Details anti-CLASP2 Antibody

Target: CLASP2 (Cytoplasmic Linker Associated Protein 2 (CLASP2))

Binding Specificity: AA 946-975, C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CLASP2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This CLASP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 946-975 amino acids from the C-terminal region of human CLASP2.

Clone: RB9127

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. IHC-P: 1:50~100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

Target Details for CLASP2

Target: CLASP2 (Cytoplasmic Linker Associated Protein 2 (CLASP2))

Alternative Name: CLASP2 (CLASP2 Products)

Synonyms: zgc:77279 antibody, DKFZp459M112 antibody, 1500004F14Rik antibody, 8030404L10Rik antibody, C77448 antibody, CLASP2beta antibody, mKIAA0627 antibody, cytoplasmic linker associated protein 2 antibody, CLIP associating protein 2 antibody, clasp2 antibody, CLASP2 antibody, Clasp2 antibody

Background: Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle.

Molecular Weight: 141064

Gene ID: 23122

NCBI Accession: NP_001193973, NP_055912

UniProt: O75122

Pathways: Microtubule Dynamics, Maintenance of Protein Location