MAPK11 antibody (AA 133-161)

Catalog No. ABIN391731

This anti-MAPK11 antibody is a Rabbit Polyclonal antibody detecting MAPK11 in WB. Suitable for Human and Mouse.

Quick Overview for MAPK11 antibody (AA 133-161) (ABIN391731)

Target: MAPK11 (Mitogen-Activated Protein Kinase 11 (MAPK11))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MAPK11 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB6828

Product Details anti-MAPK11 Antibody

Binding Specificity: AA 133-161

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This MAPK11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 133-161 amino acids from the Central region of human MAPK11.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C.

Expiry Date: 6 months

Target Details for MAPK11

Target: MAPK11 (Mitogen-Activated Protein Kinase 11 (MAPK11))

Alternative Name: p38 beta

Background: P38 beta is a member of the MAP kinase subfamily of Ser/Thr protein kinases. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is closely related to p38 MAP kinase, both of which can be activated by changes in osmolarity of the extracellular environment, proinflammatory cytokines and cellular stress. This protein preferentially phosphorylates transcription factor ATF2. It is activated by phosphorylation on threonine and tyrosine by MKK6, and inhibited by pyridinyl-imidazole related compounds. Highest levels of expression are found in the brain and heart, with additional expression in the placenta, lung, liver, skeletal muscle, kidney and pancreas.

Molecular Weight: 41357

NCBI Accession: NP_002742

UniProt: Q15759

Pathways: MAPK Signaling, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Response to Water Deprivation, Regulation of Muscle Cell Differentiation, ER-Nucleus Signaling, Hepatitis C, Toll-Like Receptors Cascades, Signaling Events mediated by VEGFR1 and VEGFR2, Thromboxane A2 Receptor Signaling, BCR Signaling, S100 Proteins