MAK antibody (C-Term)

Catalog No. ABIN391782

Cited in 2+ publications. The Rabbit Polyclonal anti-MAK antibody (Clone RB3342) (ABIN391782) specifically detects MAK in WB and IHC (p). The antibody is reactive with Human samples.

Quick Overview for MAK antibody (C-Term) (ABIN391782)

Target: MAK (Male Germ Cell-Associated Kinase (MAK))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MAK antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB3342

Product Details anti-MAK Antibody

Binding Specificity: AA 578-608, C-Term

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This MAK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 578-608 amino acids from the C-terminal region of human MAK.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-MAK antibody (ABIN391782)

Li, Rao, Zheng-Le, Hurd, Lillo, Khanna: "Loss of retinitis pigmentosa 2 (RP2) protein affects cone photoreceptor sensory cilium elongation in mice." in: Cytoskeleton (Hoboken, N.J.), (2015) (PubMed).

Tucker, Scheetz, Mullins, DeLuca, Hoffmann, Johnston, Jacobson, Sheffield, Stone: "Exome sequencing and analysis of induced pluripotent stem cells identify the cilia-related gene male germ cell-associated kinase (MAK) as a cause of retinitis pigmentosa." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 108, Issue 34, pp. E569-76, (2011) (PubMed).

Target Details for MAK

Target: MAK (Male Germ Cell-Associated Kinase (MAK))

Alternative Name: MAK

Background: MAK is a serine/threonine protein kinase related to kinases involved in cell cycle regulation. It is expressed almost exclusively in the testis, primarily in germ cells. Studies of the mouse and rat homologs have localized the kinase to the chromosomes during meiosis in spermatogenesis, specifically to the synaptonemal complex that exists while homologous chromosomes are paired. There is, however, a study of the mouse homolog that has identified high levels of expression in developing sensory epithelia so its function may be more generalized.

Molecular Weight: 70581

Gene ID: 4117

NCBI Accession: NP_001229314, NP_001229886, NP_005897

UniProt: P20794