MAPK15 antibody (N-Term)

Catalog No. ABIN391796

Product Details anti-MAPK15 Antibody

Target: MAPK15 (Mitogen-Activated Protein Kinase 15 (MAPK15))

Binding Specificity: AA 32-61, N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MAPK15 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This MAPK15 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 32-61 amino acids from the N-terminal region of human MAPK15.

Clone: RB12573

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. WB: 1:1000. IHC-P: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-MAPK15 antibody (ABIN391796)

Groehler, Lannigan: "A chromatin-bound kinase, ERK8, protects genomic integrity by inhibiting HDM2-mediated degradation of the DNA clamp PCNA." in: The Journal of cell biology, Vol. 190, Issue 4, pp. 575-86, (2010) (PubMed).

Target Details for MAPK15

Target: MAPK15 (Mitogen-Activated Protein Kinase 15 (MAPK15))

Alternative Name: MAPK15 (ERK8) (MAPK15 Products)

Synonyms: MGC138052 antibody, MGC99048 antibody, erk7 antibody, zgc:110345 antibody, ERK7 antibody, ERK8 antibody, BC048082 antibody, Erk7 antibody, ATMPK15 antibody, F25P22.9 antibody, F25P22_9 antibody, MAP kinase 15 antibody, mitogen-activated protein kinase 15 antibody, mitogen-activated protein kinase 15 L homeolog antibody, MAP kinase 15 antibody, MAPK15 antibody, mapk15.L antibody, mapk15 antibody, Tsp_00300 antibody, Mapk15 antibody, MPK15 antibody

Background: The ERKs are a subfamily of the MAPKs that have been implicated in cell growth and differentiation. Extracellular signal-regulated kinase 8 (Erk8) is a large MAP kinase whose activity is controlled by serum and the c-Src non-receptor tyrosine kinase. ERK8 down-regulates transactivation of the glucocorticoid receptor through Hic-5 and can negatively regulate transcriptional co-activation of androgen receptor and GRalpha by Hic-5 in a kinase-independent manner, suggesting a broader role for ERK8 in the regulation of nuclear receptors beyond estrogen receptor alpha. Erk8 is a novel effector of RET/PTC3 and, therefore, RET biological functions.

Molecular Weight: 59832

Gene ID: 225689

NCBI Accession: NP_620590

UniProt: Q8TD08