APOE antibody (C-Term)

Catalog No. ABIN391849

This Rabbit Polyclonal antibody specifically detects APOE in WB and IHC (p). It exhibits reactivity toward Human and Mouse.It has been mentioned in 1 publication

Quick Overview for APOE antibody (C-Term) (ABIN391849)

Target: APOE (Apolipoprotein E (APOE))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This APOE antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB15180

Product Details anti-APOE Antibody

Binding Specificity: AA 263-292, C-Term

Predicted Reactivity: Pr, Rb

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This APOE antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 263-292 amino acids from the C-terminal region of human APOE.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. IHC-P: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-APOE antibody (ABIN391849)

Benga, Krieger, Dimitrova, Zeisel, Parnot, Lupberger, Hildt, Luo, McLauchlan, Baumert, Schuster: "Apolipoprotein E interacts with hepatitis C virus nonstructural protein 5A and determines assembly of infectious particles." in: Hepatology (Baltimore, Md.), Vol. 51, Issue 1, pp. 43-53, (2009) (PubMed).

Target Details for APOE

Target: APOE (Apolipoprotein E (APOE))

Alternative Name: APOE

Background: Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III),in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants.

Molecular Weight: 36154

Gene ID: 348

NCBI Accession: NP_000032

UniProt: P02649

Pathways: Regulation of Cell Size, Lipid Metabolism