EPH Receptor B3 antibody (N-Term)

Catalog No. ABIN391922

The Rabbit Polyclonal anti-EPH Receptor B3 antibody has been validated for WB and IHC (p). It is suitable to detect EPH Receptor B3 in samples from Human. There is 1 publication available.

Quick Overview for EPH Receptor B3 antibody (N-Term) (ABIN391922)

Target: EPH Receptor B3 (EPHB3)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EPH Receptor B3 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB1653

Product Details anti-EPH Receptor B3 Antibody

Binding Specificity: AA 29-59, N-Term

Predicted Reactivity: M

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This EphB3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 29-59 amino acids from the N-terminal region of human EphB3.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. IHC-P: 1:50~100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-EPH Receptor B3 antibody (ABIN391922)

Gao, Zhang, Wang, Wang, Zhang: "EphB3 protein is associated with histological grade and FIGO stage in ovarian serous carcinomas." in: APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, Vol. 125, Issue 2, pp. 122-127, (2017) (PubMed).

Target Details for EPH Receptor B3

Target: EPH Receptor B3 (EPHB3)

Alternative Name: EphB3

Background: Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. EphB3, a member of the Tyr family of protein kinases, is a receptor for members of the ephrin-B family, it binds to both ephrin-B1 and -B2. Expression of this Type I membrane protein is ubiquitous. The protein contains putative domains for 2 fibronectin type III and 1 sterile alpha motif (SAM).

Molecular Weight: 110330

Gene ID: 2049

NCBI Accession: NP_004434

UniProt: P54753

Pathways: RTK Signaling