Fgr antibody (N-Term)

Catalog No. ABIN392096

Product Details anti-Fgr Antibody

Target: Fgr (FGR) (Gardner-Rasheed Feline Sarcoma Viral (V-Fgr) Oncogene Homolog (FGR))

Binding Specificity: AA 3-33, N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Fgr antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This FGR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 3-33 amino acids from the N-terminal region of human FGR.

Clone: RB3095

Isotype: Ig Fraction

Application Details

Application Notes: IF: 1:10~50. WB: 1:1000. WB: 1:2000. WB: 1:1000. IHC-P: 1:50~100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-Fgr antibody (ABIN392096)

Henderson, Gonzales, Arora, Choudhary, Trent, Von Hoff, Mousses, Azorsa: "High-throughput RNAi screening identifies a role for TNK1 in growth and survival of pancreatic cancer cells." in: Molecular cancer research : MCR, Vol. 9, Issue 6, pp. 724-32, (2011) (PubMed).

Tatarov, Mitchell, Seywright, Leung, Brunton, Edwards: "SRC family kinase activity is up-regulated in hormone-refractory prostate cancer." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 15, Issue 10, pp. 3540-9, (2009) (PubMed).

Target Details for Fgr

Target: Fgr (FGR) (Gardner-Rasheed Feline Sarcoma Viral (V-Fgr) Oncogene Homolog (FGR))

Alternative Name: FGR (FGR Products)

Background: FGR is a member of the Src family of protein tyrosine kinases (PTKs). This protein contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. It localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this protein.

Molecular Weight: 59479

Gene ID: 2268

NCBI Accession: NP_001036194, NP_001036212, NP_005239

UniProt: P09769

Pathways: Sensory Perception of Sound, Stem Cell Maintenance, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, CXCR4-mediated Signaling Events, Thromboxane A2 Receptor Signaling