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TRIB1 antibody (C-Term)

TRIB1 Reactivity: Human WB Host: Rabbit Polyclonal RB9762 unconjugated
Catalog No. ABIN392118
  • Target See all TRIB1 Antibodies
    TRIB1 (Tribbles Homolog 1 (TRIB1))
    Binding Specificity
    • 15
    • 10
    • 7
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 341-370, C-Term
    Reactivity
    • 55
    • 14
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 49
    • 4
    • 3
    Rabbit
    Clonality
    • 53
    • 3
    Polyclonal
    Conjugate
    • 21
    • 5
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This TRIB1 antibody is un-conjugated
    Application
    • 42
    • 27
    • 13
    • 13
    • 7
    • 6
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Predicted Reactivity
    M
    Purification
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogen
    This TRIB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 341-370 amino acids from the C-terminal region of human TRIB1.
    Clone
    RB9762
    Isotype
    Ig Fraction
    Top Product
    Discover our top product TRIB1 Primary Antibody
  • Application Notes
    WB: 1:2000. WB: 1:2000. WB: 1:1000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Expiry Date
    6 months
  • Makishima, Boonvisut, Ishizuka, Watanabe, Nakayama, Iwamoto: "Sin3A-associated protein, 18 kDa, a novel binding partner of TRIB1, regulates MTTP expression." in: Journal of lipid research, Vol. 56, Issue 6, pp. 1145-52, (2015) (PubMed).

    Ishizuka, Nakayama, Ogawa, Makishima, Boonvisut, Hirao, Iwasaki, Yada, Yanagisawa, Miyashita, Takahashi, Iwamoto: "TRIB1 downregulates hepatic lipogenesis and glycogenesis via multiple molecular interactions." in: Journal of molecular endocrinology, Vol. 52, Issue 2, pp. 145-58, (2014) (PubMed).

    Dugast, Kiss-Toth, Docherty, Danger, Chesneau, Pichard, Judor, Pettré, Conchon, Soulillou, Brouard, Ashton-Chess: "Identification of tribbles-1 as a novel binding partner of Foxp3 in regulatory T cells." in: The Journal of biological chemistry, Vol. 288, Issue 14, pp. 10051-60, (2013) (PubMed).

  • Target
    TRIB1 (Tribbles Homolog 1 (TRIB1))
    Alternative Name
    TRIB1 (TRIB1 Products)
    Synonyms
    TRIB1 antibody, c8fw antibody, gig2 antibody, skip1 antibody, trb1 antibody, tribbles antibody, C8FW antibody, GIG2 antibody, SKIP1 antibody, TRB1 antibody, A530090O15Rik antibody, TRB-1 antibody, Trb1 antibody, Gig2 antibody, tribbles pseudokinase 1 antibody, tribbles pseudokinase 1 L homeolog antibody, tribbles homolog 1 (Drosophila) antibody, TRIB1 antibody, trib1 antibody, trib1.L antibody, Trib1 antibody
    Background
    TRIB1 antibody, also called gprotein coupled receptor induced, skip1, gig2, c8fwATP, functions in binding protein binding, protein kinase inhibitor activity, and protein serine/threonine kinase activities. Overexpression of TRIB1 in HeLa cells repressed the basal activity of the IL8 promoter by inhibiting AP1 activity. Overexpression of TRIB1 inhibited oncogenic Ras -driven AP1 activation and MEKK1-mediated AP1 activation. ERK activation was enhanced by TRIB1. Coimmunoprecipitation and yeast 2-hybrid assays showed that MEK1 interacted with both TRIB1 and TRIB3, and MKK4 interacted specifically with TRIB1. Cotransfection of MKK4 enhanced the level of TRIB1, indicating that the TRIB-MAPKK interaction stabilized TRIB1.
    Molecular Weight
    41009
    Gene ID
    10221
    NCBI Accession
    NP_079471
    UniProt
    Q96RU8
    Pathways
    Smooth Muscle Cell Migration
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