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MAP3K10 antibody (Mitogen-Activated Protein Kinase Kinase Kinase 10) (AA 628-659) Primary Antibody

MAP3K10 Reactivity: Human IHC (p), WB Host: Rabbit Polyclonal RB0986 unconjugated
Pubmed (2)
Catalog No. ABIN392424
$423.50
Plus shipping costs $45.00
400 μL ABIN392424
400 μL ABIN392424
local_shipping Shipping to: United States
Delivery in 10 to 11 Business Days
  • Target
    MAP3K10
    Binding Specificity
    • 15
    • 9
    • 9
    • 8
    • 7
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 628-659, C-Term
    Reactivity
    • 56
    • 23
    • 10
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 53
    • 3
    Rabbit
    Clonality
    • 56
    Polyclonal
    Conjugate
    • 21
    • 7
    • 6
    • 4
    • 4
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This MAP3K10 antibody is un-conjugated
    Application
    • 48
    • 38
    • 36
    • 7
    • 7
    • 6
    • 1
    • 1
    • 1
    Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
    Purification
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogen
    This MLK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 628-659 amino acids from the C-terminal region of human MLK2.
    Clone
    RB0986
    Isotype
    Ig Fraction
  • Application Notes
    WB: 1:1000. IHC-P: 1:50~100
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Expiry Date
    6 months
  • Humphrey, Newcomb, Yu, Hao, Yu, Krajewski, Du, Jhala: "Mixed lineage kinase-3 stabilizes and functionally cooperates with TRIBBLES-3 to compromise mitochondrial integrity in cytokine-induced death of pancreatic beta cells." in: The Journal of biological chemistry, Vol. 285, Issue 29, pp. 22426-36, 2010 (PubMed). Method employed by authors: Western Blotting (WB)

    Nagao, Hayashi: "Mixed lineage kinase 2 and hippocalcin are localized in Lewy bodies of Parkinson's disease." in: Journal of the neurological sciences, Vol. 281, Issue 1-2, pp. 51-4, 2009 (PubMed). Method employed by authors: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

  • Target
    MAP3K10
    Alternative Name
    MLK2 (MAP3K10 Antibody Abstract)
    Synonyms
    MEKK10, MLK2, MST, BC028668, BC046514, Mlk2, mlk2, xmlk2, mitogen-activated protein kinase kinase kinase 10, mitogen activated protein kinase kinase kinase 10, mitogen-activated protein kinase kinase kinase 10 L homeolog, MAP3K10, Map3k10, map3k10.L
    Background
    MLK2 is a member of the serine/threonine kinase family. This kinase has been shown to activate MAPK8/JNK and MKK4/SEK1, and this kinase itself can be phoshorylated, and thus activated by JNK kinases. This kinase functions preferentially on the JNK signaling pathway, and is reported to be involved in nerve growth factor (NGF) induced neuronal apoptosis.
    Molecular Weight
    103694
    Gene ID
    4294
    NCBI Accession
    NP_002437
    UniProt
    Q02779
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