PKN beta antibody (C-Term)

Catalog No. ABIN392444

The Rabbit Polyclonal anti-PKN beta antibody is suitable to detect PKN beta in samples from Human. It has been validated for WB and IHC (p).

Quick Overview for PKN beta antibody (C-Term) (ABIN392444)

Target: PKN beta

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PKN beta antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB1043

Product Details anti-PKN beta Antibody

Binding Specificity: AA 463-492, C-Term

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This PKN beta antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 463-492 amino acids from the C-terminal region of human PKN beta.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:500. IHC-P: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

Target Details for PKN beta

Target: PKN beta

Background: PKN3, a protein kinase C-related molecule, mediates malignant cell growth downstream of activated PI3K. PKN3 is required for invasive prostate cell growth as assessed by 3D cell culture assays and in an orthotopic mouse tumor model by inducible expression of short hairpin RNA (shRNA). PKN3 is regulated by PI3K at both the expression level and the catalytic activity level. Therefore, PKN3 might represent a preferred target for therapeutic intervention in cancers that lack tumor suppressor PTEN function or depend on chronic activation of PI3K.

Molecular Weight: 99421

Gene ID: 29941

NCBI Accession: NP_037487

UniProt: Q6P5Z2