NPR1 antibody (N-Term)

Catalog No. ABIN392702

There are 3+ publications for this product available. The Rabbit Polyclonal anti-NPR1 antibody is suitable to detect NPR1 in samples from Human, Mouse and Rat. It has been validated for IHC (p).

Quick Overview for NPR1 antibody (N-Term) (ABIN392702)

Target: NPR1 (Natriuretic Peptide Receptor A/guanylate Cyclase A (Atrionatriuretic Peptide Receptor A) (NPR1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NPR1 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB03496

Product Details anti-NPR1 Antibody

Binding Specificity: AA 1-30, N-Term

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This Natriuretic Peptide Receptor A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human Natriuretic Peptide Receptor A.

Isotype: Ig Fraction

Application Details

Application Notes: IHC-P: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze-thaw cycles.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots.

Expiry Date: 6 months

References for anti-NPR1 antibody (ABIN392702)

Abdelalim, Masuda, Tooyama: "Expression of natriuretic peptide-activated guanylate cyclases by cholinergic and dopaminergic amacrine cells of the rat retina." in: Peptides, Vol. 29, Issue 4, pp. 622-8, (2008) (PubMed).

Dams, Van Acker, Gustin, Vereycken, Bunkens, Holemans, Smeulders, Clayton, Ohagen, Hertogs: "A time-resolved fluorescence assay to identify small-molecule inhibitors of HIV-1 fusion." in: Journal of biomolecular screening, Vol. 12, Issue 6, pp. 865-74, (2007) (PubMed).

Tomescot, Leschik, Bellamy, Dubois, Messas, Bruneval, Desnos, Hagège, Amit, Itskovitz, Menasché, Pucéat: "Differentiation in vivo of cardiac committed human embryonic stem cells in postmyocardial infarcted rats." in: Stem cells (Dayton, Ohio), Vol. 25, Issue 9, pp. 2200-5, (2007) (PubMed).

Target Details for NPR1

Target: NPR1 (Natriuretic Peptide Receptor A/guanylate Cyclase A (Atrionatriuretic Peptide Receptor A) (NPR1))

Alternative Name: Natriuretic Peptide Receptor A (NPR1/ANPA)

Background: ANPA is a receptor for atrial natriuretic peptide. It exhibits guanylate cyclase activity on binding of ANF. There seem to be at least three ANP receptors: two with guanylate cyclase activity (ANPA and ANPB) and one (ANPC) which is probably responsible for the clearance of ANP from the circulation without a role in signal transduction. This Type I membrane protein belongs to the adenylyl cyclase class-4/guanylyl cyclase family and contains 1 protein kinase-like domain.

Molecular Weight: 118919

Gene ID: 4881

NCBI Accession: NP_000897

UniProt: P16066