EIF2AK1 antibody (AA 267-296)

Catalog No. ABIN392708

The Rabbit Polyclonal anti-EIF2AK1 antibody is suitable to detect EIF2AK1 in samples from Human. It has been validated for WB and IHC (p).

Quick Overview for EIF2AK1 antibody (AA 267-296) (ABIN392708)

Target: EIF2AK1 (Eukaryotic Translation Initiation Factor 2-alpha Kinase 1 (EIF2AK1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EIF2AK1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB12521

Product Details anti-EIF2AK1 Antibody

Binding Specificity: AA 267-296

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This HRI (EIF2AK1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 267-296 amino acids from the Central region of human HRI (EIF2AK1).

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. IHC-P: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C.

Expiry Date: 6 months

Target Details for EIF2AK1

Target: EIF2AK1 (Eukaryotic Translation Initiation Factor 2-alpha Kinase 1 (EIF2AK1))

Alternative Name: HRI (EIF2AK1)

Background: The HRI gene is localized to 7p22 where its 3' end slightly overlaps the 3' end of the gene JTV1. The two genes are transcribed from opposite strands. Studies in rat and rabbit suggest that the HRI gene product phosphorylates the alpha subunit of eukaryotic initiation factor 2. Its kinase activity is induced by low levels of heme and inhibited by the presence of heme.

Molecular Weight: 71106

NCBI Accession: NP_001127807, NP_055228

UniProt: Q9BQI3

Pathways: Hepatitis C