SIK2 antibody

Catalog No. ABIN400680

The Mouse Monoclonal anti-SIK2 antibody (Clone S15G10) (ABIN400680) specifically detects SIK2 in WB, IP, ICC, IF and IHC (p). The antibody is reactive with Human samples.

Quick Overview for SIK2 antibody (ABIN400680)

Target: SIK2 (Salt-Inducible Kinase 2 (SIK2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This SIK2 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: S15G10

Product Details anti-SIK2 Antibody

Characteristics: Synonyms: SIK-2, SNF1LK2, QIK, Serine/threonine-protein kinase SIK2, Salt-inducible protein kinase 2,Serine/threonine-protein kinase SNF1-like kinase 2, Qin-induced kinase

Purification: Affinity Chromatography.

Immunogen: Recombinant Human SIK2.

Isotype: IgG1

Application Details

Application Notes: Western blot. Immunoprecipitation. Immunofluorescence. Immunohistochemistry on Paraffin Sections: 10 µg/ml. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS, pH 7.2 containing 0.09% Sodium Azide as preservative.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store the antibody undiluted at 2-8°C. DO NOT FREEZE! Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for SIK2

Target: SIK2 (Salt-Inducible Kinase 2 (SIK2))

Alternative Name: SIK2

Background: Snf1lk2 belongs to the Ser/Thr protein kinase family, AMPK subfamily. It has one proteinkinase domain and one UBA domain. Snf1lk2 requires magnesium as a cofactor andphosphorylates Ser-794 of IRS1 in insulin-stimulated adipocytes. This potentiallymodulates the efficiency of insulin signal transduction. It also inhibits CREB activity byphosphorylating and repressing the CREB-specific coactivators, CRTC1-3. Snf1lk2 isactivated by phosphorylation on Thr-175 by STK11 in complex with STE20-relatedadapter-alpha (STRAD alpha) pseudo kinase and CAB39.

UniProt: Q9H0K1