FBXW11 antibody (N-Term)

Catalog No. ABIN401257

This Rabbit Polyclonal antibody specifically detects FBXW11 in WB and EIA. It exhibits reactivity toward Human, Mouse, Dog, Cow, Horse, Chicken and Chimpanzee.

Quick Overview for FBXW11 antibody (N-Term) (ABIN401257)

Target: FBXW11 (F-Box and WD Repeat Domain Containing 11 (FBXW11))

Reactivity: Human, Mouse, Dog, Cow, Horse, Chicken, Chimpanzee

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FBXW11 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Product Details anti-FBXW11 Antibody

Binding Specificity: N-Term

Specificity: This antibody reacts with betaTrCP2 protein.

Cross-Reactivity (Details): Species reactivity (expected):Mouse, Canine, Bovine, Chimpanzee, Chicken, Horse.
Species reactivity (tested):Human.

Purification: Affinity chromatography

Immunogen: Synthetic peptide corresponding to a region near the N-terminal of human betaTrCP2 protein

Isotype: IgG

Application Details

Application Notes: ELISA: 1/10,000 - 1/100,000. Western Blot: 1/200 - 1/1,000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL (by UV absorbance at 280 nm)

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 containing 0.01 % (w/v) Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Target Details for FBXW11

Target: FBXW11 (F-Box and WD Repeat Domain Containing 11 (FBXW11))

Alternative Name: FBW1B

Background: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class and, in addition to an F-box, contains multiple WD40 repeats. This gene contains at least 14 exons, and its alternative splicing generates 3 transcript variants diverging at the presence/absence of two alternate exons.Synonyms: BTRCP2, F-box and WD repeats protein beta-TrCP2, F-box/WD repeat-containing protein 11, F-box/WD repeat-containing protein 1B, FBXW11, FBXW1B, HOS, Homologous to Slimb protein, KIAA0696, beta-TrCP2

Gene ID: 23291

NCBI Accession: NP_036432

UniProt: Q9UKB1