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FBXW11 antibody (AA 1-140)

FBXW11 Reactivity: Human IHC, ELISA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7152490
  • Target See all FBXW11 Antibodies
    FBXW11 (F-Box and WD Repeat Domain Containing 11 (FBXW11))
    Binding Specificity
    • 7
    • 7
    • 6
    • 6
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-140
    Reactivity
    • 26
    • 8
    • 5
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    Human
    Host
    • 24
    • 2
    Rabbit
    Clonality
    • 24
    • 2
    Polyclonal
    Conjugate
    • 16
    • 2
    • 2
    • 2
    • 2
    • 2
    This FBXW11 antibody is un-conjugated
    Application
    • 22
    • 17
    • 15
    • 13
    • 4
    • 2
    • 2
    • 1
    Immunohistochemistry (IHC), ELISA
    Cross-Reactivity
    Human
    Purification
    Antigen Affinity Purified
    Immunogen
    Recombinant Human F-box/WD repeat-containing protein 11 protein (1-140AA)
    Isotype
    IgG
    Top Product
    Discover our top product FBXW11 Primary Antibody
  • Application Notes
    Recommended dilution: IHC:1:20-1:200,
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,-80 °C
    Storage Comment
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    FBXW11 (F-Box and WD Repeat Domain Containing 11 (FBXW11))
    Alternative Name
    FBXW11 (FBXW11 Products)
    Synonyms
    BTRC2 antibody, BTRCP2 antibody, FBW1B antibody, FBXW1B antibody, Fbw11 antibody, Hos antibody, 2310065A07Rik antibody, AA536858 antibody, Fbxw1b antibody, HOS antibody, btrc2 antibody, fbxw11a antibody, wu:fa12e12 antibody, wu:fb11f03 antibody, zgc:63728 antibody, fbxw11 antibody, fbxw11b antibody, fbxw1b antibody, wu:fd14d12 antibody, wu:fi43f07 antibody, F-box and WD repeat domain containing 11 antibody, F-box and WD-40 domain protein 11 antibody, F-box/WD repeat-containing protein 11 antibody, F-box and WD repeat domain containing 11b antibody, F-box and WD repeat domain containing 11a antibody, FBXW11 antibody, Fbxw11 antibody, LOC100199403 antibody, fbxw11b antibody, fbxw11a antibody
    Background

    Background: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. SCF(FBXW11) mediates the ubiquitination of phosphorylated CTNNB1 and participates in Wnt signaling. SCF(FBXW11) mediates the ubiquitination of phosphorylated NFKBIA, which degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. SCF(FBXW11) mediates the ubiquitination of IFNAR1. Involved in the oxidative stress-induced a ubiquitin-mediated decrease in RCAN1. Mediates the degradation of CDC25A induced by ionizing radiation in cells progressing through S phase and thus may function in the intra-S-phase checkpoint. Has an essential role in the control of the clock-dependent transcription via degradation of phosphorylated PER1 and phosphorylated PER2. Is target of human immunodeficiency virus type 1 (HIV-1) protein VPU to polyubiquitinate and deplete BST2 from cells and antagonize its antiviral action.

    Aliases: beta Transducin Repeat Containing Protein 2 antibody, BTRC2 antibody, BTRCP2 antibody, F-box and WD repeats protein beta-TrCP2 antibody, F-box and WD-40 Domain Protein 1B antibody, F-box Protein FBW1B antibody, F-box/WD repeat-containing protein 11 antibody, F-box/WD repeat-containing protein 1B antibody, FBW1B antibody, FBW1B_HUMAN antibody, FBXW11 antibody, FBXW1B antibody, Homologous to Slimb protein antibody, HOS antibody

    UniProt
    Q9UKB1
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