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FANCF antibody (Internal Region)

FANCF Reactivity: Human, Chimpanzee WB, EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN401270
  • Target See all FANCF Antibodies
    FANCF (Fanconi Anemia, Complementation Group F (FANCF))
    Binding Specificity
    • 6
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reactivity
    • 18
    • 2
    • 1
    Human, Chimpanzee
    Host
    • 15
    • 2
    • 2
    Rabbit
    Clonality
    • 18
    • 1
    Polyclonal
    Conjugate
    • 9
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This FANCF antibody is un-conjugated
    Application
    • 11
    • 6
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Enzyme Immunoassay (EIA)
    Specificity
    This affinity purified antibody is directed against FANCF protein.
    Cross-Reactivity (Details)
    Species reactivity (expected):Chimpanzee (100 %).
    Species reactivity (tested):Human.
    Purification
    Immunoaffinity chromatography
    Immunogen
    Synthetic peptide corresponding to an internal amino acid sequence of human FANCF
    Isotype
    IgG
    Top Product
    Discover our top product FANCF Primary Antibody
  • Application Notes
    ELISA: 1: 15,000 - 1: 60,000. Western blot: 1: 1,000 - 1: 5,000 (Expect a band approximately 42 kDa in size correspondingto FANCF in the appropriate human tissue).
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    1.19 mg/mL (by UV absorbance at 280 nm)
    Buffer
    0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2, 0.01 % (w/v) Sodium Azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing. Should this product contain a precipitate we recommend microcentrifugation before use.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer.
  • Target
    FANCF (Fanconi Anemia, Complementation Group F (FANCF))
    Alternative Name
    FANCF (FANCF Products)
    Synonyms
    FAF antibody, A730016A17 antibody, RGD1561456 antibody, Fanconi anemia complementation group F L homeolog antibody, Fanconi anemia, complementation group F antibody, Fanconi anemia complementation group F antibody, fancf.L antibody, fancf antibody, FANCF antibody, Fancf antibody
    Background
    FANCF (also called Protein FACF or Fanconi Anemia Group F protein) is involved in DNA repair, perhaps specifically with post-replication repair or a cell cycle checkpoint function. FANCF has also been implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. FANCF belongs to the multi-subunit Fanconi Anemia (FA) complex composed of FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9 and FANCM. The complex is not found in FA patients. FANCF is found within the nucleus. Defects in FANCF are a cause of Fanconi anemia (FA). FA is a genetically heterogeneous, autosomal recessive disorder characterized by progressive pancytopaenia, a diverse assortment of congenital malformations, and a predisposition to the development of malignancies. At the cellular level, it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage), and defective DNA repair.Synonyms: FACF, Fanconi anemia group F protein
    Gene ID
    2188
    NCBI Accession
    NP_073562
    UniProt
    Q9NPI8
    Pathways
    DNA Damage Repair
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