PTENP1 antibody (N-Term)

Catalog No. ABIN401437

This Rabbit Polyclonal antibody specifically detects PTENP1 in WB and EIA. It exhibits reactivity toward Human, Chimpanzee, Dog, Macaque, Mouse, Rat, Green Pufferfish and Zebrafish (Danio rerio).

Quick Overview for PTENP1 antibody (N-Term) (ABIN401437)

Target: PTENP1 (Phosphatase and Tensin Homolog Pseudogene 1 (PTENP1))

Reactivity: Human, Chimpanzee, Dog, Macaque, Mouse, Rat, Green Pufferfish, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PTENP1 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Product Details anti-PTENP1 Antibody

Binding Specificity: N-Term

Cross-Reactivity (Details): Species reactivity (expected):Mouse, Rat, Canine, Macaque, Chimpanzee, Opossum, Zebrafish, Green pufferfish, Platypus.
Species reactivity (tested):Human.

Purification: Affinity chromatography

Immunogen: Purified peptide corresponding to amino acids near the N-terminal end of human PTEN-P1 protein

Isotype: IgG

Application Details

Application Notes: ELISA: 1/160,000. Western Blot: 1/500 to 1/2,000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 0.73 mg/mL (by UV absorbance at 280 nm)

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 containing 0.01 % (w/v) Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Target Details for PTENP1

Target: PTENP1 (Phosphatase and Tensin Homolog Pseudogene 1 (PTENP1))

Alternative Name: PTENP1

Background: This gene (PTENP1) is a highly homologous pseudogene of PTEN. PTEN was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. PTEN is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tension like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway.Synonyms: PTEN-rs, PTEN2, PTH2, Phosphatase and tensin homolog 2, Phosphatase and tensin homolog pseudogene 1, psiPTEN

Gene ID: 9606

UniProt: O43460