PTENP1 antibody (N-Term)

Catalog No. ABIN349585

Product Details anti-PTENP1 Antibody

Target: PTENP1 (Phosphatase and Tensin Homolog Pseudogene 1 (PTENP1))

Binding Specificity: N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PTENP1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Specificity: This affinity-purified antibody is directed against human PTEN-P1 protein. The product was affinity purified from monospecific antiserum by immunoaffinity purification.  Reactivity occurs against human PTEN-P1 protein.   A BLAST analysis was used to suggest cross reactivity with PTEN proteins from mouse,

Characteristics: This gene (PTENP1) is a highly homologous pseudogene of PTEN. PTEN was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. PTEN is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tension like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway.

Purification: affinity purified

Sterility: Sterile filtered

Immunogen: This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a peptide corresponding to amino acids near the N-terminal end of human PTEN-P1 protein.
Immunogen Type: Peptide

Isotype: IgG

Application Details

Application Notes: This affinity purified antibody has been tested for use in ELISA and western blot.  Specific conditions for reactivity should be optimized by the end user. Expect a band approximately 55 kDa in size corresponding to PTEN-P1 protein by western blotting in the appropriate cell lysate or extract.

Comment:

Gene Name: PTENP1

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.15 mg/mL

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Store vial at 4 °C prior to restoration. For extended storage aliquot contents and freeze at -20 °C or below. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4 °C as an undiluted liquid. Dilute only prior to immediate use. Expiration date is three (3) months from date of opening.

Expiry Date: 3 months

Target Details for PTENP1

Target: PTENP1 (Phosphatase and Tensin Homolog Pseudogene 1 (PTENP1))

Alternative Name: PTEN-P1 (PTENP1 Products)

Synonyms: PTEN-rs antibody, PTEN2 antibody, PTENpg1 antibody, PTH2 antibody, psiPTEN antibody, phosphatase and tensin homolog pseudogene 1 antibody, PTENP1 antibody

Background: This gene (PTENP1) is a highly homologous pseudogene of PTEN.  PTEN was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. PTEN is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tension like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway.
Synonyms: Phosphatase and tensin homolog pseudogene 1 antibody, psiPTEN antibody, PTEN rs antibody, PTEN2 antibody, PTH2 antibody, TEP1 antibody

Gene ID: 5728, 73765544

UniProt: O43460