Metabotropic Glutamate Receptor 6 antibody (C-Term)

Catalog No. ABIN437971

This Rabbit Polyclonal antibody specifically detects Metabotropic Glutamate Receptor 6 in WB, IHC and ICC. It exhibits reactivity toward Rat and Mouse.

Quick Overview for Metabotropic Glutamate Receptor 6 antibody (C-Term) (ABIN437971)

Target: Metabotropic Glutamate Receptor 6 (GRM6) (Glutamate Receptor, Metabotropic 6 (GRM6))

Reactivity: Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Metabotropic Glutamate Receptor 6 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC)

Product Details anti-Metabotropic Glutamate Receptor 6 Antibody

Binding Specificity: C-Term

Purification: affinity purified

Immunogen: AAPPQNENAEDAK
Corresponding to the carboxyterminus of rat mGluR6

Isotype: IgG

Application Details

Application Notes: Suggested dilutions:
Western blot: 1:2000-1:3000
Immunohistochemistry: 1:300
Dilutions listed as a recommendation. Optimal dilution should be determined by investigator

Comment:

This antibody is useful for Western blot, where a band is seen at approx. 96 kDa. Neurons of expected brain regions stain well. Staining is not recommended for human or rat tissues
Note: A customer found a band in the 60-70 kDa range corresponding to the mGluR6 precursor.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 0.1 % BSA, Tris-glycine with 0.1 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Aliquot as undiluted antisera and immediately place at -20°C.
Antisera may have become trapped in top of vial during shipping. Centrifugation of vial is recommended before opening.
Repeated freeze/thaw cycles compromise the integrity of the antiserum.

Storage: -20 °C

Expiry Date: 6 months

Target Details for Metabotropic Glutamate Receptor 6

Target: Metabotropic Glutamate Receptor 6 (GRM6) (Glutamate Receptor, Metabotropic 6 (GRM6))

Alternative Name: mGluR6

Background: Metabotropic glutamate receptors (mGluRs) are G-protein coupled receptors activated by glutamate. Based on sequence similarity, transduction mechanisms and agonist potencies, mGluRs are subdivided into three groups: mGluR1/mGluR5, mGluR2/mGluR3, and mGluR4/mGluR6/mGluR7/mGluR8. mGluRs are widely distributed throughout the nervous system and are expressed by both neurons and glial cells. mGluRs have been suggested to play a variety of functional roles, among which is involvement in synaptic plasticity underlying learning and memory as well as chronic pain.