KDELR1 antibody

Catalog No. ABIN452265

The Mouse Monoclonal anti-KDELR1 antibody (Clone KR-10) (ABIN452265) specifically detects KDELR1 in WB, IF, IP and IHC (fro). The antibody is reactive with Various Species samples.

Quick Overview for KDELR1 antibody (ABIN452265)

Target: KDELR1 (KDEL (Lys-Asp-Glu-Leu) Endoplasmic Reticulum Protein Retention Receptor 1 (KDELR1))

Reactivity: Various Species

Host: Mouse

Clonality: Monoclonal

Conjugate: This KDELR1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro))

Clone: KR-10

Product Details anti-KDELR1 Antibody

Cross-Reactivity (Details): Species reactivity (tested):Human, Monkey, Mouse, Rat, Hamster, Rabbit, Pig, Bovine, Sheep, Canine, Chicken, Drosphilia, Xenopus

Characteristics: Synonyms: KDEL endoplasmic reticulum protein retention receptor 1, ERD2.1, ER marker, ER lumenprotein retaining receptor 1, Putative MAPK-activating protein PM23

Purification: Protein G chromatography

Immunogen: A 21 residue synthetic peptide based on the bovine KDEL receptor and the peptide coupledto KLH

Isotype: IgG1

Application Details

Application Notes: Immunoprecipitation (1). Immunocytochemistry (3). Immunohistochemisztry on frozen sections. Western blot (2).

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS pH 7.2, in 50 % glycerol with 0.09 % azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer. Avoidrepeated freezing and thawing.
Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for KDELR1

Target: KDELR1 (KDEL (Lys-Asp-Glu-Leu) Endoplasmic Reticulum Protein Retention Receptor 1 (KDELR1))

Alternative Name: KDEL Receptor 1 / KDELR1

Background: The endoplasmic reticulum is part of a protein sorting pathway, or in essence, the transportation system of the eukaryotic cell. The majority of endoplasmic reticulum resident proteins are retained in the endoplasmic reticulum through a retention motif. This motif is composed of four amino acids at the C-terminal end of the protein sequence. The most common retention sequence is KDEL (lys-asp-glu-leu). However, variation on KDEL does occur and other sequences can also give rise to endoplasmic reticulum retention (6). There are three KDEL receptors in mammalian cells, all have a very high degree of sequence identity, and all are located within the cis-Golgi and its intermediate compartments (4). In terms of function, KDEL receptors interact with GAP (GTPase-activating protein) of ARF1, which is involved in COPI dependent vesicle transport, and the KDEL receptor may also be responsible for the recruitment of this ARF1 to membranes which can then aid in the regulation of vesicle budding (3). It is also important to note that the KDEL receptor exhibits extensive sequence identity o yeast protein Erd2p, which is a receptor for the yeast ER retention signal (4, 5).Synonyms: ER lumen protein retaining receptor 1, ER marker, ERD2.1, KDEL endoplasmic reticulum protein retention receptor 1, Putative MAPK-activating protein PM23

Gene ID: 618184

UniProt: P33946

Pathways: Maintenance of Protein Location