FKBP4 antibody (Middle Region)

Catalog No. ABIN453015

The Rabbit Polyclonal anti-FKBP4 antibody (ABIN453015) specifically detects FKBP4 in WB and EIA. The antibody is reactive with Human samples.

Quick Overview for FKBP4 antibody (Middle Region) (ABIN453015)

Target: FKBP4 (FK506 Binding Protein 4, 59kDa (FKBP4))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FKBP4 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Product Details anti-FKBP4 Antibody

Binding Specificity: Middle Region

Specificity: This antibody detects FKBP4 at Center.

Cross-Reactivity (Details): Species reactivity (tested):Human

Purification: Prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS

Immunogen: KLH conjugated synthetic peptide selected from the Center region of human FKBP4

Application Details

Application Notes: Western blot: 1: 50 - 1: 100. ELISA: 1: 1,000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.09 % (W/V) sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer.

Target Details for FKBP4

Target: FKBP4 (FK506 Binding Protein 4, 59kDa (FKBP4))

Alternative Name: FKBP4

Background: FKBP4 is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It has high structural and functional similarity to FK506-binding protein 1A (FKBP1A), but unlike FKBP1A, this protein does not have immunosuppressant activity when complexed with FK506. It interacts with interferon regulatory factor-4 and plays an important role in immunoregulatory gene expression in B and T lymphocytes. This protein is known to associate with phytanoyl-CoA alpha-hydroxylase. It can also associate with two heat shock proteins (hsp90 and hsp70) and thus may play a role in the intracellular trafficking of hetero-oligomeric forms of the steroid hormone receptors. This protein correlates strongly with adeno-associated virus type 2 vectors (AAV) resulting in a significant increase in AAV-mediated transgene expression in human cell lines. Thus this protein is thought to have important implications for the optimal use of AAV vectors in human gene therapy.Synonyms: 52 kDa FK506-binding protein, FK506-binding protein 4, FKBP52 protein, FKBP59, HBI, HSP-binding immunophilin, PPIase, Peptidyl-prolyl cis-trans isomerase, Rotamase, p59 protein

Molecular Weight: 51805 Da

Gene ID: 2288

NCBI Accession: NP_002005

UniProt: Q02790

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway