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SIGLEC12 antibody (C-Term)

SIGLEC12 Reactivity: Human, Mouse WB, EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN453827
  • Target See all SIGLEC12 Antibodies
    SIGLEC12 (Sialic Acid Binding Ig-Like Lectin 12 (SIGLEC12))
    Binding Specificity
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    • 27
    • 14
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Mouse
    Host
    • 28
    • 3
    • 1
    Rabbit
    Clonality
    • 30
    • 2
    Polyclonal
    Conjugate
    • 20
    • 6
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This SIGLEC12 antibody is un-conjugated
    Application
    • 24
    • 11
    • 8
    • 3
    • 3
    • 3
    • 2
    Western Blotting (WB), Enzyme Immunoassay (EIA)
    Specificity
    This antibody reacts to SIGLEC12.
    Purification
    Saturated Ammonium Sulfate (SAS) precipitation
    Immunogen
    KLH conjugated synthetic peptide selected from the C-terminal region of human SIGLEC12
    Top Product
    Discover our top product SIGLEC12 Primary Antibody
  • Application Notes
    ELISA: 1/1,000. Western blotting: 1/50 - 1/100.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.25 mg/mL
    Buffer
    PBS with 0.09 % (W/V) sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Target
    SIGLEC12 (Sialic Acid Binding Ig-Like Lectin 12 (SIGLEC12))
    Alternative Name
    SIGLEC12 (SIGLEC12 Products)
    Synonyms
    S2V antibody, SIGLECL1 antibody, SLG antibody, Siglec-XII antibody, sialic acid binding Ig like lectin 12 (gene/pseudogene) antibody, sialic acid binding Ig like lectin 12 antibody, sialic acid binding Ig-like lectin 12 antibody, SIGLEC12 antibody
    Background
    Sialic acid-binding immunoglobulin-like lectins (SIGLECs) are a family of cell surface proteins belonging to the immunoglobulin superfamily. They mediate protein-carbohydrate interactions by selectively binding to different sialic acid moieties present on glycolipids and glycoproteins. SIGLEC12 is a member of the SIGLEC3-like subfamily of SIGLECs. Members of this subfamily are characterized by an extracellular V-set immunoglobulin-like domain followed by two C2-set immunoglobulin-like domains, and the cytoplasmic tyrosine-based motifs ITIM and SLAM-like. This protein, upon tyrosine phosphorylation, has been shown to recruit the Src homology 2 domain-containing protein-tyrosine phosphatases SHP1 and SHP2. It has been suggested that the protein is involved in the negative regulation of macrophage signaling by functioning as an inhibitory receptor.Synonyms: SIGLECL1, SLG, Sialic acid-binding Ig-like lectin 12, Sialic acid-binding Ig-like lectin-like 1, Siglec-12, Siglec-L1
    Gene ID
    89858
    NCBI Accession
    NP_443729
    UniProt
    Q96PQ1
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