This antibody reacts with natural and recombinant IL-16. No cross-reactivity with Human Serum Albumin, Bovine Serum Albumin and other cytokines or growth factors tested such as IL-1beta, TGF-beta1, TNF-alpha, IL-8, IL-7, MCP-1, EGF, bFGF, GM-CSF.
IL16
Reactivity: Human
WB, ELISA
Host: Rabbit
Polyclonal
unconjugated
Application Notes
ELISA. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions
For Research Use only
Format
Liquid
Buffer
0.01 M PBS, pH 7.0 ± 0.1 in 50 % Glycerol and 0.01 % Thimerosal as a bacteriostat
Preservative
Thimerosal (Merthiolate)
Precaution of Use
This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
Avoid repeated freezing and thawing.
Storage
-20 °C
Storage Comment
Store the antibody at -20 °C. Can be shipped at 2 - 8 °C.
Target
IL16
(Interleukin 16 (IL16))
Alternative Name
Interleukin-16 / IL16
Background
IL16 is a proinflammatory cytokine that is chemotactic for CD4+ T lymphocytes, monocytes, and eosinophils. IL16 is synthesized as a precursor molecule (pro IL16) of approximately 68 kDa and 631 amino acid residues lacking a signal peptide. The sequence and structure of IL16 is conserved across species. In addition to inducing chemotaxis, IL16 upregulates the IL2 receptor and upregulates HLADR expression. It also inhibits T cell receptor (TCR)/CD3 dependent activation, and suppresses HIV1 replication in vitro. Sources of IL16 include epithelial cells, mast cells, T lymphocytes (CD4+ and CD8+), macrophages, synovial fibroblasts, and eosinophils.Synonyms: IL-16, LCF, Lymphocyte chemoattractant factor