C6 antibody (C-Term)

Catalog No. ABIN461987

Product Details anti-C6 Antibody

Target: C6 (Complement Component 6 (C6))

Binding Specificity: C-Term

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This C6 antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA, Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Brand: IHC-plus™

Specificity: Recognizes complement component 6 (C6) a 104 kD member of the complement C6/C7/C8/C9 family present in blood serum. The factor I modules of C6 bind the C terminus of the C5b alpha-chain, anchoring the molecule to the membrane and also binds complement component 7. This enables the formation of the C5b-7 precursor complex. C5b-7 then functions as a receptor for components C8 and C9 which form the complement membrane attack complex (MAC). Deficiency of C6 results in susceptibility to bacterial infection. Recognizes MAC.

Purification: Protein A purified

Immunogen: Purified human C6.

Clone: 056B-214-2-4-2

Isotype: IgG1

Application Details

Application Notes: Approved: ELISA, Flo, IHC, IHC-P (10 μg/mL)

Usage: Immunohistochemistry: This antibody was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in  pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration for this antibody was determined to be 10 μg/mL. Histology Positive Control Tissue: Kidney from post streptococcal glomerulonephritis patients.

Comment:

Target Species of Antibody: Human

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Borate buffered saline, 0.09 % sodium azide. Sourced in Ascites.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing. Store undiluted.

Storage: 4 °C,-20 °C

Storage Comment: 4°C or -20°C, Avoid freeze-thaw cycles. Store undiluted.

Target Details for C6

Target: C6 (Complement Component 6 (C6))

Alternative Name: Complement C6 (C6 Products)

Synonyms: zgc:64073 antibody, MGC82168 antibody, c6 antibody, MGC89471 antibody, C6 antibody, AW111623 antibody, complement component 6 antibody, complement C6 antibody, complement component 6, gene 1 L homeolog antibody, complement component 6, gene 2 antibody, c6 antibody, C6 antibody, c6.1.L antibody, c6.2 antibody

Background: Name/Gene ID: C6

Synonyms: C6, Complement component C6, Complement C6, Complement component 6

Gene ID: 729

UniProt: P13671