SPHK2 antibody (C-Term)

Catalog No. ABIN4620337

This Rabbit Polyclonal antibody specifically detects SPHK2 in WB and EIA. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for SPHK2 antibody (C-Term) (ABIN4620337)

Target: SPHK2 (Sphingosine Kinase 2 (SPHK2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SPHK2 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Product Details anti-SPHK2 Antibody

Binding Specificity: C-Term

Specificity: This antibody reacts to SPHK2.

Purification: Affinity Purified

Immunogen: Synthetic peptide derived from the C-terminal of Sphingosine Kinase 2

Isotype: IgG

Application Details

Application Notes: Western Blot: 1: 200. ELISA. Positive Control: Active Recombinant Sphingosine Kinase Enzyme.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: Phosphate buffered saline with 0.08 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: The antibody can be shipped on dry ice. Store (in aliquots) at -20 °C only.

Target Details for SPHK2

Target: SPHK2 (Sphingosine Kinase 2 (SPHK2))

Alternative Name: Sphingosine Kinase 2 / SPK2

Background: Sphingosine Kinase 2 (Sphk2) catalyzes the phosphorylation of sphingosine to sphingosine 1-phosphate (S1P), an important signaling molecule with intra- and extracellular functions. Inside the cell S1P acts as a signaling molecule like other sphingolipid metabolites like ceramide and sphingosine. S1P has been implicated in regulating cell differentiation, calcium mobilization from intracellular stores, and apoptosis. The cell surface receptors for S1P are the EDG family of G protein-coupled receptors (S1P Receptors). These receptors couple to multiple G proteins (e.g. S1P1 couples to Gi whereas S1P2 and S1P3 couple to Gq, G13 in addition to Gi) and regulate a extremely wide range of cellular events including cell motility, survival, apoptosis, migration and cell-cell interaction. Important roles for S1P have also been reported in regulation of cardiogenesis, vascular maturation, oocyte survival, immune cell trafficking, cells of the neuronal system and bone cells. S1P levels are regulated by the activity of Sphk (Sphk1 and Sphk2).Synonyms: SK2, SPHK2

Gene ID: 56848

NCBI Accession: NP_064511

UniProt: Q9NRA0

Pathways: VEGF Signaling