Sphingomyelin Synthase 1 antibody

Catalog No. ABIN4620352

Product Details anti-Sphingomyelin Synthase 1 Antibody

Target: Sphingomyelin Synthase 1 (SGMS1)

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Sphingomyelin Synthase 1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro)), Enzyme Immunoassay (EIA)

Specificity: This antibody detects Sphingomyelin Synthase 1, expressed in brain, heart, kidney, liver, muscle and stomach.

Purification: Ligand Affinity Chromatography

Immunogen: Synthetic peptide derived from the Human Sphingomyelin Synthase 1 protein

Application Details

Application Notes: ELISA. Western Blot: (5-10 g). Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline with 0.08 % Sodium Azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for Sphingomyelin Synthase 1

Target: Sphingomyelin Synthase 1 (SGMS1)

Alternative Name: TMEM23 / SGMS1 (SGMS1 Products)

Background: A bidirectional lipid cholinephosphotransferases capable of converting phosphatidylcholine (PC) and ceramide to sphingomyelin (SM) and diacylglycerol (DAG) and the inverse reaction. Direction is dependent on the relative concentrations of DAG and ceramide as phosphocholine acceptors. Directly and specifically recognizes the choline head group on the substrate. Also requires two fatty chains on the choline-P donor molecule in order to be recognized efficiently as a substrate. May not function strictly as a SM synthase. Inhibited by bacterial PC-phospholipase C inhibitor D609. Localized to Golgi apparatus, Golgi membrane, multi-pass membrane protein. Possibly present on Brain, heart, kidney, liver, muscle and stomach.Synonyms: MOB, Medulla oblongata-derived protein, Phosphatidylcholine:ceramide cholinephosphotransferase 1, SMS1, Sphingomyelin synthase 1, Transmembrane protein 23

Gene ID: 259230

NCBI Accession: NP_671512

UniProt: Q86VZ5

Pathways: Cellular Response to Molecule of Bacterial Origin