PTCHD2 antibody (Middle Region)

Catalog No. ABIN4620591

Product Details anti-PTCHD2 Antibody

Target: PTCHD2 (Patched Domain Containing 2 (PTCHD2))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PTCHD2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Cross-Reactivity (Details): Species reactivity (tested):Human, Mouse, Rat

Purification: Affinity chromatography purified via peptide column

Immunogen: 19 amino acid synthetic peptide from near the center of human PTCHD2

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for PTCHD2

Target: PTCHD2 (Patched Domain Containing 2 (PTCHD2))

Alternative Name: PTCHD2 (PTCHD2 Products)

Synonyms: DISP3 antibody, G630052C06Rik antibody, RNDEu-2 antibody, RGD1305820 antibody, dispatched RND transporter family member 3 antibody, patched domain-containing protein 2 antibody, si:dkey-32e23.6 antibody, DISP3 antibody, LOC100082708 antibody, si:dkey-32e23.6 antibody, disp3 antibody, Disp3 antibody

Background: PTCHD2, also known as DISP3, is the third of three known homologs of the D. melanogaster protein Dispatched. It is a multi-transmembrane protein containing two PTCH/DISP domains and is thought to be involved in the release of lipid-anchored secreted proteins. Like DISP1 and DISP2, DISP3 has been implicated in signaling pathways during embryogenesis, tissue regeneration, and carcinogenesis. It is highly expressed in Purkinje cells, hippocampal neurons, and retinal ganglion cells. Recently, it has been shown that PTCHD2 localizes within the endoplasmic reticulum and colocalizes with cholesterol, and given that its expression is regulated by thyroid hormone (T3), it has been suggested that DISP3 may be a link between thyroid hormone and cholesterol metabolism.Synonyms: DISP3, KIAA1337, Patched domain-containing protein 2, Protein dispatched homolog 3

Gene ID: 57540

UniProt: Q9P2K9