Defensin antibody

Catalog No. ABIN481654

This Mouse Monoclonal antibody specifically detects Defensin in IHC and IHC (p). It exhibits reactivity toward Human.

Quick Overview for Defensin antibody (ABIN481654)

Target: Defensin (DEF)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Application: Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: Def-3

Product Details anti-Defensin Antibody

Specificity: Several defensins are recognized, the epitope has not been further characterized. Biological functions: Various functions have been described for defensins. They are antibacterial, antifungal, chemotactic for monocytes, inhibitory for ACTH-induced corticosteroid synthesis and cytotoxic for cells. Defensins are inhibited by glucosaminoglycans (self protection for cells) and high concentrations of Calpha 2+ ions. Biochemistry: Defensins are a group of cyclic peptides containing 29-35 amino acids (MW < 3500) which tend to form aggregates. The molecules are protease resistant. The defensin content of azurophilic granules in neutrophils is approximately 30 % of the total protein. Specificity: Human: Defensin 1-3 (HNP-1 to HNP-3) in human neutrophils. Synthetic defensin-1 and -2 (Bachem, Bubendorf CH) stain also positively. Not tested with Defensin-4. A side reaction to elastin has been observed in humans. Other: not tested. Defensins have been described in rabbits (NP-1 to NP-5, NP3a = Corticostatin), and in mice (cryptodin).

Purification: Affinity purified

Immunogen: Native defensins

Application Details

Application Notes: Approved: IHC, IHC-P (1:1000)

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: 0.5 mL distilled water

Concentration: Lot specific

Buffer: Lyophilized from PBS  pH 7.2, 5 mg/mL BSA, 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store at 4°C.

Target Details for Defensin

Target: Defensin (DEF)

Alternative Name: DEF / Defensin

Pathways: Production of Molecular Mediator of Immune Response