Opioid Receptor (AA 341-390), (pSer375) antibody

Catalog No. ABIN481801

This Rabbit Polyclonal antibody specifically detects Opioid Receptor in WB, ELISA, IHC and IF. It exhibits reactivity toward Mouse, Rat and Human.

Quick Overview for Opioid Receptor (AA 341-390), (pSer375) antibody (ABIN481801)

Target: Opioid Receptor

Reactivity: Mouse, Rat, Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details

Binding Specificity: AA 341-390, pSer375

Purpose: MOR-1 (phospho Ser375) Antibody

Specificity: Phospho-MOR-1 (S375) Polyclonal Antibody detects endogenous levels of MOR-1 protein only when phosphorylated at S375.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Purity: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human Opioid Receptor around the phosphorylation site of Ser375. AA range:341-390

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details

Target: Opioid Receptor

Background:

Synonyms: OPRM1; MOR1; Mu-type opioid receptor; M-OR-1; MOR-1; Mu opiate receptor; Mu opioid receptor; MOP; hMOP

Background: This gene encodes one of at least three opioid receptors in humans; the mu opioid receptor (MOR). The MOR is the principal target of endogenous opioid peptides and opioid analgesic agents such as beta-endorphin and enkephalins. The MOR also has an important role in dependence to other drugs of abuse, such as nicotine, cocaine, and alcohol via its modulation of the dopamine system. The NM_001008503.2:c.118A>G allele has been associated with opioid and alcohol addiction and variations in pain sensitivity but evidence for it having a causal role is conflicting. Multiple transcript variants encoding different isoforms have been found for this gene. Though the canonical MOR belongs to the superfamily of 7-transmembrane-spanning G-protein-coupled receptors some isoforms of this gene have only 6 transmembrane domains. [provided by RefSeq, Oct 2013],

Gene Name: OPRM1

Protein Name: Mu-type opioid receptor

Molecular Weight: 44 kDa

Gene ID: 4988

OMIM: 600018

UniProt: P35372