KEAP1 antibody (C-Term)

Catalog No. ABIN4889301

This anti-KEAP1 antibody is a Rabbit Polyclonal antibody detecting KEAP1 in WB, ELISA, IF and ICC. Suitable for Human, Pig and Guinea Pig.

Quick Overview for KEAP1 antibody (C-Term) (ABIN4889301)

Target: KEAP1 (Kelch-Like ECH-Associated Protein 1 (KEAP1))

Reactivity: Human, Pig, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KEAP1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Product Details anti-KEAP1 Antibody

Binding Specificity: C-Term

Specificity: Reacts with KEAP1 from human, pig, guinea pig, sheep and other species (due to 100 % sequence homology)

Purification: Purified (protein A)

Immunogen: Synthetic peptide of derived from C terminal part of human KEAP1.

Application Details

Application Notes:

Working dilution: Optimal dilutions should be determined by the end user.
The following are guidelines only:
WB(1:500 - 1:200) ICC/ IF(1:200 - 1:1000)

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Must be reconstituted in distilled water.

Concentration: 1 mg/mL

Buffer: Tris 0,1M, glycine 0,1M

Storage: 4 °C/-20 °C

Storage Comment: Short term storage at+4°C. For extended periods store in aliquots at -20°C. Antibodies are guaranteed for 6 month from date of receipt.

Expiry Date: 6 months

Target Details for KEAP1

Target: KEAP1 (Kelch-Like ECH-Associated Protein 1 (KEAP1))

Alternative Name: KEAP1

Background: Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome.

Gene ID: 9817

UniProt: Q14145

Pathways: Maintenance of Protein Location