SUZ12 Polycomb Repressive Complex 2 Subunit (SUZ12) (C-Term) antibody

Details for Product No. ABIN4889655, Supplier: Log in to see
Antigen
  • fc31h10
  • im:7153578
  • si:dkey-10p5.2
  • suz12
  • wu:fc31h10
  • 2610028O16Rik
  • AI195385
  • AU016842
  • AW536442
  • D11Ertd530e
  • mKIAA0160
  • Xsuz12
  • chet9
  • jjaz1
  • CHET9
  • ChET 9 protein
  • JJAZ1
  • SUZ12 polycomb repressive complex 2b subunit
  • SUZ12 polycomb repressive complex 2 subunit
  • suppressor of zeste 12 homolog (Drosophila)
  • SUZ12 polycomb repressive complex 2 subunit S homeolog
  • suz12b
  • Suz12
  • SUZ12
  • suz12.S
Epitope
C-Term
7
6
5
4
3
3
3
3
3
2
1
1
1
1
Reactivity
Human, Mouse (Murine)
102
38
10
6
4
4
4
3
3
1
1
1
Host
Rabbit
69
38
Clonality
Polyclonal
Conjugate
Un-conjugated
1
1
1
Application
ChIP DNA-Sequencing (ChIPSeq), Chromatin Immunoprecipitation (ChIP), Western Blotting (WB)
98
58
33
11
11
11
10
8
6
5
3
1
1
1
Options
Supplier
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Immunogen This Suz12 antibody was raised against a peptide corresponding to the C-terminus of human Suz12.
Isotype IgG
Purification Affinity Purified
Antigen
Alternative Name Suz12 (SUZ12 Antibody Abstract)
Background Suz12 (Suppressor-of-Zeste 12 protein, also designated as ChET9, JJAZ1 protein) is a component of the Polycomb group complexes 2, 3 and 4 (PRC2, PRC33 and PRC4), which also contain the histone methyltransferase EZH2, EED (Embryonic Ectoderm Development protein) protein and the histone-binding proteins RbAP46 and RbAP48. PRC2 is responsible for di- and trimethylation of histone 3 at lysine 27 (Histone H3 dimethyl Lys27 and Histone H3 trimethyl Lys27), which leads to transcriptional repression of the target genes. Suz12 is a nuclear protein belonging to the VEFS family. Suz12 contains a zinc-finger binding motif and a VEFS box, which is required for the interaction between Suz12 and EZH2.
Molecular Weight 95 kDa
Gene ID 23512
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.56 μg/μL
Buffer 70 mM Tris ( pH 8), 105 mM NaCl, 31 mM glycine, 0.07 mM EDTA, 30 % glycerol, and 0.035 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice

Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Storage -20 °C
Storage Comment Antibodies in solution can be stored at -20 °C for 2 years.
Expiry Date 6 months
Supplier Images
ChIP DNA-Sequencing (ChIPSeq) image for anti-SUZ12 Polycomb Repressive Complex 2 Subunit (SUZ12) (C-Term) antibody (ABIN4889655) Suz12 antibody (pAb) tested by ChIP-Seq. ChIP was performed using the ChIP-IT® High S...
Chromatin Immunoprecipitation (ChIP) image for anti-SUZ12 Polycomb Repressive Complex 2 Subunit (SUZ12) (C-Term) antibody (ABIN4889655) Suz12 antibody (pAb) tested by ChIP. Chromatin immunoprecipitation (ChIP) was perform...
Western Blotting (WB) image for anti-SUZ12 Polycomb Repressive Complex 2 Subunit (SUZ12) (C-Term) antibody (ABIN4889655) Suz12 antibody (pAb) tested by Western blot. HeLa cell nuclear extract (25 μg) was pr...
Product cited in: Toth, Papp, Brulois, Choi, Gao, Jung: "LANA-Mediated Recruitment of Host Polycomb Repressive Complexes onto the KSHV Genome during De Novo Infection." in: PLoS pathogens, Vol. 12, Issue 9, pp. e1005878, 2016 (PubMed).

Kumar, Duester: "Retinoic acid controls body axis extension by directly repressing Fgf8 transcription." in: Development (Cambridge, England), Vol. 141, Issue 15, pp. 2972-7, 2014 (PubMed).

McLaughlin, Wang, Saifudeen, El-Dahr: "In situ histone landscape of nephrogenesis." in: Epigenetics, Vol. 9, Issue 2, pp. 222-35, 2014 (PubMed).

Rossetto, Tarrant-Elorza, Pari: "Cis and trans acting factors involved in human cytomegalovirus experimental and natural latent infection of CD14 (+) monocytes and CD34 (+) cells." in: PLoS pathogens, Vol. 9, Issue 5, pp. e1003366, 2013 (PubMed).

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