Annexin a1 antibody (AA 130-180)

Catalog No. ABIN4900980

This anti-Annexin a1 antibody is a Rabbit Polyclonal antibody detecting Annexin a1 in WB, ELISA and IHC (p). Suitable for Human.

Quick Overview for Annexin a1 antibody (AA 130-180) (ABIN4900980)

Target: Annexin a1 (ANXA1) (Annexin A1 (ANXA1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Annexin a1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-Annexin a1 Antibody

Binding Specificity: AA 130-180

Purpose: Annexin I is a protein encoded by the ANXA1 gene which is approximately 38,7 kDa. Annexin I is localised to the cell membrane. It is involved in peptide ligand-binding receptors, signalling by GPCR, cytokine signalling in immune system and RET signalling. It is a membrane-localized protein that binds phospholipids and plays an important role in the innate immune response as an effector of glucocorticoid-mediated responses and is a regulator of the inflammatory process. Annexin I is expressed in resting neutrophils. Mutations in the ANXA1 gene may result in hairy cell leukemia. STJ98699 was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. This primary antibody detects endogenous Annexin I.

Specificity: The antibody detects endogenous Annexin I.

Characteristics: Rabbit Polyclonal to Annexin I.

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Immunogen: Synthetic peptide from human Annexin I protein.

Isotype: IgG

Application Details

Application Notes: WB 1:500-2000
IHC-P 1:50-300
ELISA 1:5000-20000

Comment:

Detected in resting neutrophils . Detected in peripheral blood T-cells . Detected in extracellular vesicles in blood serum from patients with inflammatory bowel disease, but not in serum from healthy donors . Detected in placenta (at protein level) . Detected in liver.

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS,  pH 7.4, containing 0.02 % sodium azide as Preservative and 50 % Glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze/thaw cycles.

Storage: -20 °C

Storage Comment: Store at -20°C, and avoid repeat freeze-thaw cycles.

Target Details for Annexin a1

Target: Annexin a1 (ANXA1) (Annexin A1 (ANXA1))

Alternative Name: Annexin I

Molecular Weight: 38kDa

Gene ID: 301

UniProt: P04083

Pathways: Hormone Transport