COPS3 antibody (AA 261-360) (Cy5.5)

Catalog No. ABIN4908225

This anti-COPS3 antibody is a Rabbit Polyclonal antibody detecting COPS3 in IF (cc) and IF (p). Suitable for Human.

Quick Overview for COPS3 antibody (AA 261-360) (Cy5.5) (ABIN4908225)

Target: COPS3 (COP9 Signalosome Complex Subunit 3 (COPS3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This COPS3 antibody is conjugated to Cy5.5

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-COPS3 Antibody (Cy5.5)

Binding Specificity: AA 261-360

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human COPS3

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for COPS3

Target: COPS3 (COP9 Signalosome Complex Subunit 3 (COPS3))

Alternative Name: COPS3

Background:

Synonyms: COP9 signalosome complex subunit 3, SGN3, Signalosome subunit 3, JAB1-containing signalosome subunit 3

Background: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.

Gene ID: 8533

Pathways: Cell Division Cycle