FZR1 antibody

Catalog No. ABIN4909759

This Mouse Monoclonal antibody specifically detects FZR1 in WB and IF. It exhibits reactivity toward Human.

Quick Overview for FZR1 antibody (ABIN4909759)

Target: FZR1 (Fizzy/cell Division Cycle 20 Related 1 (FZR1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This FZR1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Clone: 1C7

Product Details anti-FZR1 Antibody

Cross-Reactivity: Human

Purification: Purified by Protein G.

Immunogen: This FZR antibody is generated from a mouse immunized with a recombinant protein between1-496 amino acids from human FZR.

Isotype: IgG1

Application Details

Application Notes: WB 1:300-5000
IF()

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for FZR1

Target: FZR1 (Fizzy/cell Division Cycle 20 Related 1 (FZR1))

Alternative Name: FZR

Background:

Synonyms: FZR, CDH1, FZR2, HCDH, HCDH1, CDC20C, Fizzy-related protein homolog, CDC20-like protein 1, Cdh1/Hct1 homolog, FZR1, FYR, KIAA1242

Background: Key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers substrate specificity upon the complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis.

Gene ID: 51343

UniProt: Q9UM11

Pathways: DNA Replication, Synthesis of DNA