MASTL antibody

Catalog No. ABIN4911795

Product Details anti-MASTL Antibody

Target: MASTL (Microtubule Associated serine/threonine Kinase-Like (MASTL))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This MASTL antibody is un-conjugated

Application: Western Blotting (WB)

Cross-Reactivity: Human

Purification: Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.

Immunogen: This MASTL monoclonal antibody is generated from mouse immunized with MASTL recombinant protein.

Clone: 5C3

Isotype: IgG1

Application Details

Application Notes: WB 1:300-5000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for MASTL

Target: MASTL (Microtubule Associated serine/threonine Kinase-Like (MASTL))

Alternative Name: MASTL (MASTL Products)

Synonyms: GW antibody, GWL antibody, MAST-L antibody, im:7149025 antibody, wu:fa02a12 antibody, zgc:100990 antibody, MASTL antibody, GREATWALL antibody, RP11-85G18.2 antibody, THC2 antibody, hGWL antibody, 2700091H24Rik antibody, C88295 antibody, greatwall antibody, thc2 antibody, microtubule associated serine/threonine kinase-like antibody, microtubule associated serine/threonine kinase like antibody, serine/threonine-protein kinase greatwall antibody, microtubule associated serine/threonine kinase like L homeolog antibody, mastl antibody, MASTL antibody, LOC100541707 antibody, Mastl antibody, mastl.L antibody

Background:

Synonyms: GW, GWL, THC2, MAST-L, GREATWALL, Serine/threonine-protein kinase greatwall, hGWL, Microtubule-associated serine/threonine-protein kinase-like, MASTL

Background: Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance. Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of ARPP19 and ENSA at 'Ser-62' and 'Ser-67', respectively. ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D (PR55-delta) subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity high. Following DNA damage, it is also involved in checkpoint recovery by being inhibited. Phosphorylates histone protein in vitro, however such activity is unsure in vivo. May be involved in megakaryocyte differentiation.

Gene ID: 84930

UniProt: Q96GX5