Complement Factor H antibody

Catalog No. ABIN492503

The Mouse Monoclonal anti-Complement Factor H antibody is suitable to detect Complement Factor H in samples from Human. It has been validated for WB, IP, FACS, IHC (p) and EIA.

Quick Overview for Complement Factor H antibody (ABIN492503)

Target: Complement Factor H (CFH)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Complement Factor H antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Clone: OX-24

Product Details anti-Complement Factor H Antibody

Specificity: Clone OX-24 inhibits the binding of factor H to surface bound C3. This antibody recognizes the Human serum complement protein factor H and a 43-49 kDa truncated form of factor H.

Cross-Reactivity (Details): Species reactivity (tested):Human.

Characteristics: Synonyms: CFH, HF, HF1, HF2, H factor 1

Purification: Protein G Chromatography.

Immunogen: Purified Human complement factor H protein

Isotype: IgG1

Application Details

Application Notes: ELISA. Western blot. Immunoprecipitation. Flow Cytometry. Immunohistochemistry on Paraffin Sections: 20 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for Complement Factor H

Target: Complement Factor H (CFH)

Background: Factor H (CFH) is a protein with twenty short consensus repeat (SCR) domains. Factor H is secreted into the bloodstream and has an essential role in the regulation of complement activation, restricting this innate defense mechanism to microbial infections. Mutations in Factor H have been associated with hemolytic-uremic syndrome (HUS) and chronic hypocomplementemic nephropathy. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.Synonyms: CFH, H factor 1, HF, HF1, HF2

Gene ID: 3075

UniProt: P08603

Pathways: Complement System, Cellular Response to Molecule of Bacterial Origin