PTH antibody (N-Term)

Catalog No. ABIN4949381

The Rabbit Polyclonal anti-PTH antibody (ABIN4949381) specifically detects PTH in IHC (p). The antibody is reactive with Human samples.

Quick Overview for PTH antibody (N-Term) (ABIN4949381)

Target: PTH (Parathyroid Hormone (PTH))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PTH antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Grade: Carrier-free

Product Details anti-PTH Antibody

Binding Specificity: N-Term

Purpose: PTH Antibody / N-Terminal (azide and preservative free)

Purification: Protein A affinity chromatography

Immunogen: A synthetic peptide from the N-terminal region of human Parathyroid hormone was used as the immunogen for the PTH antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the PTH antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: 4 °C,-20 °C

Storage Comment: Store the PTH antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for PTH

Target: PTH (Parathyroid Hormone (PTH))

Alternative Name: PTH

Target Type: Hormone

Background: PTH/Parathyroid hormone is a hormone produced by the parathyroid gland that regulates the concentration of calcium and phosphorus in extracellular fluid. This hormone elevates blood Ca2+ levels by dissolving the salts in bone and preventing their renal excretion. It is produced in the parathyroid gland as an 84 amino acid single chain polypeptide. It can also be secreted as N-terminal truncated fragments or C-terminal fragments after intracellular degradation, as in case of hypercalcemia. Defects in this gene are a cause of familial isolated hypoparathyroidism (FIH), also called autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps. FIH exist both as autosomal dominant and recessive forms of hypoparathyroidism.

UniProt: P01270

Pathways: cAMP Metabolic Process, Regulation of Carbohydrate Metabolic Process