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Recombinant ACTH antibody (AA 1-24)

ACTH Reactivity: Human, Rat, Mouse IHC (p) Host: Mouse Monoclonal r57 unconjugated Recombinant Antibody
Catalog No. ABIN4949427
  • Target See all ACTH Antibodies
    ACTH (Adrenocorticotropic hormone (ACTH))
    Antibody Type
    Recombinant Antibody
    Binding Specificity
    • 34
    • 33
    • 19
    • 15
    • 14
    • 8
    • 2
    • 2
    AA 1-24
    Reactivity
    • 115
    • 80
    • 46
    • 3
    • 3
    • 1
    • 1
    Human, Rat, Mouse
    Host
    • 81
    • 52
    Mouse
    Clonality
    • 81
    • 52
    Monoclonal
    Conjugate
    • 49
    • 12
    • 6
    • 6
    • 6
    • 6
    • 6
    • 6
    • 6
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    This ACTH antibody is un-conjugated
    Application
    • 71
    • 69
    • 68
    • 68
    • 35
    • 33
    • 25
    • 25
    • 23
    • 18
    • 11
    • 10
    • 4
    • 3
    • 1
    • 1
    • 1
    Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Purification
    Protein G affinity chromatography
    Immunogen
    An N-terminal peptide (within AA 1-24) from the Synacthen/ACTH region of human POMC was used as the immunogen for this recombinant ACTH antibody.
    Clone
    R57
    Isotype
    IgG1
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    Discover our top product ACTH Primary Antibody
  • Application Notes
    The optimal dilution of the recombinant ACTH antibody for each application should be determined by the researcher.\. Immunohistochemistry (FFPE): 0.5-1 μg/mL for 30 minutes at RT
    Restrictions
    For Research Use only
  • Concentration
    0.2 mg/mL
    Buffer
    0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Store the recombinant ACTH antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
  • Target
    ACTH (Adrenocorticotropic hormone (ACTH))
    Alternative Name
    ACTH / POMC (ACTH Products)
    Synonyms
    ACTH antibody, BE antibody, Beta-LPH antibody, Clip antibody, Gamma-LPH antibody, Npp antibody, Pomc-1 antibody, Pomc1 antibody, alpha-MSH antibody, alphaMSH antibody, beta-MSH antibody, gamma-MSH antibody, CLIP antibody, LPH antibody, MSH antibody, NPP antibody, POC antibody, pro-opiomelanocortin-alpha antibody, proopiomelanocortin antibody, Pomc antibody, POMC antibody
    Background
    ACTH (same as Corticotropin) is a 39 amino acid active peptide produced by the anterior pituitary. This mAb is specific to Synacthen (aa1-24 of ACTH), does not react with CLIP (aa17-39 of ACTH). POMC (pro-opiomelanocortin or corticotropin-lipotropin) is a 267 amino acid polypeptide hormone precursor that goes through extensive, tissue-specific posttranslational processing by convertases. POMC is cleaved into ten hormone chains named NPP, ACTH, alpha-MSH (Melanocyte Stimulating Hormone), beta-MSH, gamma-MSH, CLIP (corticotropin-like intermediary peptide), Lipotropin-beta, Lipotropin-gamma, beta-endorphin and Met-enkephalin. ACTH is also produced by cells of immune system (T-cells, B-cells, and macrophages) in response to stimuli associated with stress. Anti-ACTH is a useful marker in classification of pituitary tumors and the study of pituitary disease. It reacts with ACTH-producing cells (corticotrophs). It also may react with other tumors (e.g. some small cell carcinomas of the lung) causing paraneoplastic syndromes by secreting ACTH.
    Pathways
    Metabolism of Steroid Hormones and Vitamin D, Peptide Hormone Metabolism, Hormone Activity
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