CD80 antibody

Catalog No. ABIN4949540

This anti-CD80 antibody is a Mouse Monoclonal antibody detecting CD80 in FACS, ELISA and IF. Suitable for Human.

Quick Overview for CD80 antibody (ABIN4949540)

Target: CD80

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD80 antibody is un-conjugated

Application: Flow Cytometry (FACS), ELISA, Immunofluorescence (IF)

Clone: C80-1608

Product Details anti-CD80 Antibody

Purification: Protein G affinity chromatography

Immunogen: Recombinant human protein used as the immunogen for the CD80 antibody.

Isotype: IgG1 kappa

Application Details

Application Notes: Optimal dilution of the CD80 antibody should be determined by the researcher.\. Flow Cytometry: 0.5-1 μg/million cells in 0.1ml,Immunofluorescence: 1-2 μg/mL,ELISA (protein): order BSA free formulation for coating

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: 4 °C,-20 °C

Storage Comment: Store the CD80 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).

Target Details for CD80

Target: CD80

Alternative Name: CD80 / B7-1

Background: T cell proliferation and lymphokine production are triggered by occupation of the TCR by antigen, followed by a costimulatory signal that is delivered by a ligand expressed on antigen presenting cells. The B7-related cell surface proteins CD80 (B7-1) and CD86 (B7-2) are expressed on antigen presenting cells bind the homologous T cell receptors CTLA-4 (cytotoxic T lymphocyte-associated protein-4) and CD28 and trigger costimulatory signals for optimal T cell activation. CTLA-4 shares 31 % overall amino acid identity with CD28 and it has been proposed that CD28 and CTLA-4 are functionally redundant. SLAM is a novel receptor on T cells that, when engaged, potentiates T cell expansion in a CD28-independent manner. B7, also designated BB1, is another ligand or counter receptor for CD28 and CTLA-4 that is expressed on the antigen-presenting cell.

Pathways: TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Positive Regulation of Immune Effector Process, Cancer Immune Checkpoints