KRT15 antibody (C-Term)

Catalog No. ABIN4949584

The Mouse Monoclonal anti-KRT15 antibody is suitable to detect KRT15 in samples from Human and Rat. It has been validated for IHC (p).

Quick Overview for KRT15 antibody (C-Term) (ABIN4949584)

Target: KRT15 (Keratin 15 (KRT15))

Reactivity: Human, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This KRT15 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Grade: Carrier-free

Clone: LHK15

Product Details anti-KRT15 Antibody

Binding Specificity: C-Term

Purpose: Keratin 15 Antibody (azide and preservative free)

Purification: Protein G affinity chromatography

Immunogen: A 17 amino acid sequence from the C- terminal of human CK15 was used as the immunogen for the Keratin 15 antibody.

Isotype: IgG2a, kappa

Application Details

Application Notes: Optimal dilution of the Keratin 15 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: 4 °C,-20 °C

Storage Comment: Store the Keratin 15 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for KRT15

Target: KRT15 (Keratin 15 (KRT15))

Alternative Name: Keratin 15

Background: Keratins are a family of intermediate filament proteins that assemble into filaments through forming heterodimers of one type I keratin (keratins 9 to 23) and one type II keratin (keratins 1 to 8). Keratins demonstrate tissue and differentiation specific expression profiles. Keratin 15 is a type I keratin which is expressed only in basal keratinocytes in stratified epithelia and does not appear to have a natural type II expression partner. Keratin 15 is down regulated in activated keratinocytes. Cytokeratin 15 is a specific marker of stem cells of the hair-follicle bulge and may be a useful marker for diagnosis between basal cell carcinoma (BCC) and trichoepithelioma. Trichoblastoma are benign neoplasms of follicular differentiation frequently found in nevus sebaceous. Many morphologic features are shared with nodular basal cell carcinoma, sometimes rendering a diagnosis difficult. Trichoblastoma and BCC show variable expression of Cytokeratin 15 and Cytokeratin 19, and absence of hair keratins.

UniProt: P19012