LGALS1/Galectin 1 antibody (AA 12-108)

Catalog No. ABIN4949704

The Mouse Monoclonal anti-LGALS1/Galectin 1 antibody has been validated for WB, ELISA, FACS, IF and IHC (p). It is suitable to detect LGALS1/Galectin 1 in samples from Human.

Quick Overview for LGALS1/Galectin 1 antibody (AA 12-108) (ABIN4949704)

Target: LGALS1/Galectin 1 (LGALS1) (Lectin, Galactoside-Binding, Soluble, 1 (LGALS1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This LGALS1/Galectin 1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: GAL1-1831

Product Details anti-LGALS1/Galectin 1 Antibody

Binding Specificity: AA 12-108

Purification: Protein G affinity chromatography

Immunogen: A human partial recombinant protein corresponding to amino acids 12-108 was used as the immunogen for the Galectin 1 antibody.

Isotype: IgG1 lambda

Application Details

Application Notes: Titering of the Galectin 1 antibody may be required for optimal performance.\. ELISA: 2-4 μg/mL, order the BSA-free formulation for coating,IF: 1-2 μg/mL,Flow Cytometry: 0.5-1 μg/million cells in 0.1ml,WB: 0.5-1 μg/mL,IHC (FFPE): 0.5-1 μg/mL for 30 min at RT

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: 4 °C,-20 °C

Storage Comment: Store the Galectin 1 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).

Target Details for LGALS1/Galectin 1

Target: LGALS1/Galectin 1 (LGALS1) (Lectin, Galactoside-Binding, Soluble, 1 (LGALS1))

Alternative Name: Galectin 1

Background: Galectin 1 is a member of the beta-galactoside-binding family and is a dimeric protein of 14 kDa participating in a variety of normal and pathological processes, including cancer progression. Galectin 1 can affect the proliferation of normal and malignant cells. Inhibition of cell growth is observed in a lactose-dependent manner as lower concentrations of the lectin stimulate cell proliferation. Galectin 1 may also be implicated in the induction of apoptosis of activated T cells through the binding of exogenous galectin-1 to CD45 Molecules present on the surface of lymphocytes. Galectin 1, reported to be present either at the surface of cancer cells or accumulated around these cells could act as an immunological shield to protect against a T cell immune response and provide an advantage for survival.

Pathways: Carbohydrate Homeostasis