BCL10 antibody (AA 1-233)

Catalog No. ABIN4950310

The Rabbit Polyclonal anti-BCL10 antibody has been validated for WB. It is suitable to detect BCL10 in samples from Human and Rat.

Quick Overview for BCL10 antibody (AA 1-233) (ABIN4950310)

Target: BCL10 (B-Cell CLL/lymphoma 10 (BCL10))

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BCL10 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-BCL10 Antibody

Binding Specificity: AA 1-233

Purification: Antigen affinity

Immunogen: Amino acids 1-233 of human Bcl10 were used as the immunogen for the Bcl10 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the Bcl10 antibody should be determined by the researcher.\. Western blot: 0.1-0.5 μg/mL

Restrictions: For Research Use only

Handling

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: -20 °C

Storage Comment: After reconstitution, the Bcl10 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Target Details for BCL10

Target: BCL10 (B-Cell CLL/lymphoma 10 (BCL10))

Alternative Name: Bcl10

Background: BCL10, B-cell CLL/lymphoma 10, gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The BCL10 gene is mapped to chromosome 1p22. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. And this protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy.

UniProt: O95999

Pathways: TCR Signaling, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Tube Formation, Positive Regulation of Endopeptidase Activity, BCR Signaling, Ubiquitin Proteasome Pathway, S100 Proteins