HTRA2 antibody

Catalog No. ABIN4953263

The Mouse Monoclonal anti-HTRA2 antibody (Clone 8G11-4B8-4F10-G5) (ABIN4953263) specifically detects HTRA2 in WB and IP. The antibody is reactive with Human samples.

Quick Overview for HTRA2 antibody (ABIN4953263)

Target: HTRA2 (HtrA Serine Peptidase 2 (HTRA2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This HTRA2 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP)

Clone: 8G11-4B8-4F10-G5

Product Details anti-HTRA2 Antibody

Purpose: HtrA2 Antibody

Purification: Protein G affinity

Immunogen: A human recombinant protein was used as the immunogen for this HtrA2 antibody.

Isotype: IgG1

Application Details

Application Notes: The stated application concentrations are suggested starting points. Titration of the HtrA2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In PBS with 50 % glycerol and 0.03 % ProClin 300

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store the HtrA2 antibody at -20oC.

Target Details for HTRA2

Target: HTRA2 (HtrA Serine Peptidase 2 (HTRA2))

Alternative Name: HtrA2

Background: Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Cleaves THAP5 and promotes its degradation during apoptosis. Isoform 2 seems to be proteolytically inactive. [UniProt]

UniProt: O43464

Pathways: Positive Regulation of Endopeptidase Activity