SIRT6 antibody

Catalog No. ABIN4953432

Product Details anti-SIRT6 Antibody

Target: SIRT6 (Sirtuin 6 (SIRT6))

Reactivity: Human, Mouse, Rat, Primate

Host: Mouse

Clonality: Monoclonal

Conjugate: This SIRT6 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunocytochemistry (ICC), Immunofluorescence (IF)

Purification: Protein G affinity

Immunogen: A human recombinant protein was used as the immunogen for this SIRT6 antibody.

Clone: 6C9-D10-D3

Isotype: IgG1

Application Details

Application Notes: The stated application concentrations are suggested starting points. Titration of the SIRT6 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:500,ICC/IF: 1:100,Immunoprecipitation: suitable

Restrictions: For Research Use only

Handling

Buffer: Antibody in PBS with 50 % Glycerol and 0.03 % ProClin 300

Storage: -20 °C

Storage Comment: Store the SIRT6 antibody at -20°C.

Target Details for SIRT6

Target: SIRT6 (Sirtuin 6 (SIRT6))

Alternative Name: SIRT6 (SIRT6 Products)

Synonyms: 2810449N18Rik antibody, AI043036 antibody, Sir2l6 antibody, SIR2L6 antibody, zgc:86729 antibody, sirtuin 6 antibody, sirtuin 6 S homeolog antibody, Sirt6 antibody, SIRT6 antibody, sirt6.S antibody, sirt6 antibody

Background: NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Acts as a corepressor of the transcription factor HIF1A to control the expression of multiple glycolytic genes to regulate glucose homeostasis. [UniProt]

UniProt: Q8N6T7