APC antibody (AA 1148-1176)

Catalog No. ABIN3029869

This Rabbit Polyclonal antibody specifically detects APC in WB and ELISA. It exhibits reactivity toward Mouse.

Quick Overview for APC antibody (AA 1148-1176) (ABIN3029869)

Target: APC (Adenomatous Polyposis Coli (APC))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This APC antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-APC Antibody

Binding Specificity: AA 1148-1176

Purpose: APC Antibody / Adenomatous polyposis coli

Purification: Antigen affinity

Immunogen: A portion of amino acids 1148-1176 from the human protein was used as the immunogen for this APC antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the APC antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles

Storage: -20 °C

Storage Comment: Aliquot the APC antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for APC

Target: APC (Adenomatous Polyposis Coli (APC))

Alternative Name: APC

Background: This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product.

UniProt: P25054

Pathways: WNT Signaling, Stem Cell Maintenance, Cell-Cell Junction Organization