BCL6 antibody (AA 676-704)

Catalog No. ABIN3030107

The Mouse Monoclonal anti-BCL6 antibody has been validated for WB and ELISA. It is suitable to detect BCL6 in samples from Human.

Quick Overview for BCL6 antibody (AA 676-704) (ABIN3030107)

Target: BCL6 (B-Cell CLL/lymphoma 6 (BCL6))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This BCL6 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Clone: 305CT16-3-3

Product Details anti-BCL6 Antibody

Binding Specificity: AA 676-704

Purification: Purified

Immunogen: A portion of amino acids 676-704 from the human protein was used as the immunogen for this BCL-6 antibody.

Isotype: IgG1 kappa

Application Details

Application Notes: Titration of the BCL-6 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:100-1:250

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the BCL-6 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Target Details for BCL6

Target: BCL6 (B-Cell CLL/lymphoma 6 (BCL6))

Alternative Name: BCL-6

Background: The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of START-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene.

UniProt: P41182

Pathways: Chromatin Binding, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Protein targeting to Nucleus