BMI1 antibody (AA 230-265)

Catalog No. ABIN3030166

This Rabbit Polyclonal antibody specifically detects BMI1 in WB and ELISA. It exhibits reactivity toward Human.

Quick Overview for BMI1 antibody (AA 230-265) (ABIN3030166)

Target: BMI1 (BMI1 Polycomb Ring Finger Oncogene (BMI1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BMI1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-BMI1 Antibody

Binding Specificity: AA 230-265

Purification: Antigen affinity purified

Immunogen: This BMI1 antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 230-265 amino acids from the C-terminal region of human BMI1.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the BMI1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000-2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the BMI1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Target Details for BMI1

Target: BMI1 (BMI1 Polycomb Ring Finger Oncogene (BMI1))

Alternative Name: BMI1

Background: Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2.

UniProt: P35226

Pathways: Cell Division Cycle, Autophagy