Caspase 10 antibody (AA 164-192)

Catalog No. ABIN3030290

The Rabbit Polyclonal anti-Caspase 10 antibody is suitable to detect Caspase 10 in samples from Human. It has been validated for WB and ELISA.

Quick Overview for Caspase 10 antibody (AA 164-192) (ABIN3030290)

Target: Caspase 10 (CASP10) (Caspase 10, Apoptosis-Related Cysteine Peptidase (CASP10))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Caspase 10 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-Caspase 10 Antibody

Binding Specificity: AA 164-192

Purification: Purified

Immunogen: A portion of amino acids 164-192 from the human protein was used as the immunogen for this Caspase-10 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the Caspase-10 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS pH 7.4 with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the Caspase-10 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Target Details for Caspase 10

Target: Caspase 10 (CASP10) (Caspase 10, Apoptosis-Related Cysteine Peptidase (CASP10))

Alternative Name: Caspase-10

Background: CASP10 is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in the protein are associated with apoptosis defects seen in type II autoimmune lymphoproliferative syndrome.

UniProt: Q92851

Pathways: Apoptosis, Caspase Cascade in Apoptosis