Cyclin D2 antibody (AA 1-30)

Catalog No. ABIN3030593

The Rabbit Polyclonal anti-Cyclin D2 antibody has been validated for WB and ELISA. It is suitable to detect Cyclin D2 in samples from Human.

Quick Overview for Cyclin D2 antibody (AA 1-30) (ABIN3030593)

Target: Cyclin D2 (CCND2)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Cyclin D2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-Cyclin D2 Antibody

Binding Specificity: AA 1-30

Purification: Antigen affinity purified

Immunogen: A portion of amino acids 1-30 from the human protein was used as the immunogen for this Cyclin D2 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the Cyclin D2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the Cyclin D2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Target Details for Cyclin D2

Target: Cyclin D2 (CCND2)

Background: The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. Knockout studies of the homologous gene in mouse suggest the essential roles of this gene in ovarian granulosa and germ cell proliferation. High level expression of this gene was observed in ovarian and testicular tumors.

UniProt: P30279

Pathways: Cell Division Cycle, Mitotic G1-G1/S Phases