DNMT1 antibody (AA 881-914)

Catalog No. ABIN3030755

The Rabbit Polyclonal anti-DNMT1 antibody has been validated for WB and ELISA. It is suitable to detect DNMT1 in samples from Human and Mouse.

Quick Overview for DNMT1 antibody (AA 881-914) (ABIN3030755)

Target: DNMT1 (DNA (Cytosine-5)-Methyltransferase 1 (DNMT1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DNMT1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-DNMT1 Antibody

Binding Specificity: AA 881-914

Purification: Antigen affinity purified

Immunogen: A portion of amino acids 881-914 from the mouse protein was used as the immungen for the Dnmt1 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the Dnmt1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:500-1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the Dnmt1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Target Details for DNMT1

Target: DNMT1 (DNA (Cytosine-5)-Methyltransferase 1 (DNMT1))

Alternative Name: Dnmt1

Background: Methylation of DNA at cytosine residues plays an important role in regulation of gene expression, genomic imprinting and is essential for mammalian development. Hypermethylation of CpG islands in tumor suppressor genes or hypomethylation of bulk genomic DNA may be linked with development of cancer. Three families of mammalian DNA methyltransferase genes have been identified which include Dnmt1, Dnmt2 and Dnmt3. Dnmt1 is constitutively expressed in proliferating cells and inactivation of this gene causes global demethylation of genomic DNA and embryonic lethality.

UniProt: P13864

Pathways: SARS-CoV-2 Protein Interactome, The Global Phosphorylation Landscape of SARS-CoV-2 Infection